Polycystic Kidney Disease causes cysts to grow in the kidneys. Autosomal dominant
PKD is the most common form of the disease, with symptoms usually develop
between the ages of 30 and 40. Common symptoms of PKD are high blood pressure,
pain related to enlarged kidneys and blood in the urine. Edema and fatigue can
also be signs of this disorder. Then what are the causes?
Edema with PKD
The kidneys are important organs to remove the water and sodium in the body.
For a person with PKD, the cysts will grow in size with age, and the enlarged
cysts will oppress the normal around tissues and damage the renal functions. So
there will be water and sodium retention in the body.
Specific causes of edema in PKD include: the decline of glomerular filtrating
function; the changes of permeability of systematic blood capillary causes the
water entry the tissue space; the decrease of plasma osmotic pressure occurs due
to reduced plasma albumin; the decrease of effective blood volume lead to an
increase of aldosterone.
Fatigue with PKD
People who have fatigue will be tired and weak all the time. They may lack
energy and may not find relief through rest. One reason for fatigue can be
anemia, a shortage of oxygen-carrying red blood cells. People with advanced
stage of PKD often have anemia due to damaged kidneys make less of a hormone
called erythropoietin, or EPO. EPO tells the bone marrow to make new red cells.
With deficient supply of RBCs, the body has less oxygen. This makes patients
more tired.
Sometimes, constant unexplained fatigue or the feeling of being tired all the
time can appear when the concentration of certain chemicals in the blood builds
up to toxic levels due to decreased kidney function.
If you are suffering from edema or fatigue with PKD, we're here to help treat
the symptoms. You can send an email to kidney-treatment@hotmail.com and our experts
will give you an detailed analysis and best treatment option.
