Patient: Chen Linzhi
Gender: Female
Age: 38
Province: Shanxi Province
Diagnosis: Bilateral Polycystic Kidney Disease
Symptoms before she went to our hospital: patients have unknown pain on waist
five years ago, and she didn’t pay attention on this symptom. Later, pain become
worsening and painful feeling did not relieve effectively after simple
treatment. In December, 2003, patient got a sudden serious pain on waist due to
excessive tiredness, and then Haematuria appeared. Though Type-B Ultrasonic
examination, liquid shadow with various sizes can be found in bilateral kidneys.
Serum creatinine is 899umol/L. patient was diagnosed as Bilateral Polycystic
Kidney Disease. Patient found the information of Shijiazhuang Kidney Disease
Hospital through website, and she came to our hospital for treatment later.
Treatment and Effect: after 10-day Micro-Chinese Medicine Osmotherapy
treatment, patient’s renal ability of excreting toxin increased, and serum
creatinine became 870umol0/L.
Patient brought medicine home for consolidating treatment.
Secondary check after one month: serum creatinine 835umol/L. through Type-B
Ultrasonic examination, bilateral cysts became smaller. Presently, symptoms of
pain on waist and Haematuria disappear. Patient’s illness condition is steady
and recovered gradually.
Expert Comment: Polycystic Kidney Disease is a kind of disease with
hereditary feature, developing with age. Traditional surgical operation can only
remove big cysts, which will leave more space for small cysts to grow. These
small cysts can grow more rapidly without pressure from big cysts. Finally, they
can damage kidney for a second time. Therefore, renal injury will be aggravated
further.
Micro-Chinese Medicine can treat PKD without surgical operation. This
treatment can improve blood circulation on cyst wall and recycle cyst internal
fluid, which can reduce cyst size. Through this way, it can relieve cystic
pressure on surrounding healthy renal tissue and repair renal function. Then
symptoms of pain on waist and Haematuria disappear.
2016年9月30日星期五
2016年9月29日星期四
Urinary Tract Infection of Polycystic Kidney Disease
Urinary tract infection which includes cystitis, nephropyelitis, cyst
infection and perinephric abscess is a common complication of PKD patients.
About 20% patients get urinary tract infection as first symptom among clinical
symptoms, and 50% t0 70% patients have urinary tract infection at least one time
during their life, especially for female patients. It has been observed in the
past that one third PKD patients who accept chronic dialysis have the symptom of
urinary tract infection. Though antibiotic is taken to deal with infection,
which can delay illness development, patients still can get perinephric abscess,
or even sometimes patients may die. There are some difficulties in treat
Polycystic Kidney Disease, especially in the aspects of preventing and treating
urinary tract infection.
Patients who suffer from PKD, complicated with cystitis, are mainly expressed by urgent urination, Odynuria and pain on pubis arch area. If infection has involved upper urinary tract, patients may have continuous high fever and waist pain. Clinically, it is some difficult to distinguish nephropyelitis from cyst infection. It is beneficial to diagnose nephropyelitis if urine culture shows positive with increasing blood leukocyte number and quick response to anti-infection treatment. While positive blood culture and pressing pain always refers to cyst infection.
When patients suspect themselves of urinary tract infection, they should accept an imaging examination. Abdominal plain film can show the position, size and numbers of urinary system stones as well as perinephric abscess. CT examination has a better sensitivity of testing perinephric abscess. As for PKD patients suffering from urinary tract infection, equipment inspection can increase the possibility of patients getting blood poisoning. For this reason, Retrograde Pyelography should be avoided.
Choosing effective antibiotics is the key of treating this disease successfully. As for patients who suffer from recurrent urinary tract infection, antibiotics are helpful to prevent infection. If equipment inspection on urinary tract is inevitable, patients should take proper antibiotic to prevent infection in 24 hours before or after treatment.
Patients who suffer from PKD, complicated with cystitis, are mainly expressed by urgent urination, Odynuria and pain on pubis arch area. If infection has involved upper urinary tract, patients may have continuous high fever and waist pain. Clinically, it is some difficult to distinguish nephropyelitis from cyst infection. It is beneficial to diagnose nephropyelitis if urine culture shows positive with increasing blood leukocyte number and quick response to anti-infection treatment. While positive blood culture and pressing pain always refers to cyst infection.
When patients suspect themselves of urinary tract infection, they should accept an imaging examination. Abdominal plain film can show the position, size and numbers of urinary system stones as well as perinephric abscess. CT examination has a better sensitivity of testing perinephric abscess. As for PKD patients suffering from urinary tract infection, equipment inspection can increase the possibility of patients getting blood poisoning. For this reason, Retrograde Pyelography should be avoided.
Choosing effective antibiotics is the key of treating this disease successfully. As for patients who suffer from recurrent urinary tract infection, antibiotics are helpful to prevent infection. If equipment inspection on urinary tract is inevitable, patients should take proper antibiotic to prevent infection in 24 hours before or after treatment.
2016年9月28日星期三
Some Questions of Polycystic Kidney Disease
Ⅰ.How does PKD treatment develop?
The reason why Polycystic Kidney Disease patients have higher serum creatinine is that patients’ cysts growing bigger gradually, which canl damage renal inherent cells, start the process of renal fibrosis and aggravate inherent cells injury furthrt. Damaged inherent cells can shrink blood vessel, which can cause High Blood Pressure. Because epithelial cells in inherent cells get damaged, they can’t prevent blood protein leakage,and then Albuminuria occurs. When inherent cells are so injured that they can not excrete more toxins, serum creatinine increases.
Ⅱ.What is the key point of causing Polycystic Kidney Disease?
Inherent cells injury caused by renal fibrosis is the real cause of Polycystic Kidney Disease. High Blood Pressure, Proteinuria, Blood Urine caused by inherent cells injury are symptoms of this disease. If patients want to cure High Blood Pressure, Proteinuria, Blood Urine, they need to cure real cause of this disease firstly.
No matter what kinds of therapeutic methods are taken, real cause of Polycystic Kidney Disease should be treated firstly. Treating disease must block Renal Fibrosis which can damage renal inherent cells. As long as the process of renal fibrosis is blocked and damaged inherent cells get repaired, symptoms of Albuminuria and Haematuria can disappear and cysts can be shrunk gradually.
The reason why disease continues for a long term is that effective treatment is not taken to block Renal Fibrosis.So the real reason why disease can’t be cured is that medicine can’t prevent the renal fibrosis from damaging renal inherent cells.
Ⅲ.How to treat Polycystic Kidney effectively?
Firstly, illness condition caused by renal inherent cells injury should be controlled firstly.
Secondly, taking proper treatment to reduce cyst fluid can relieve further pressure on renal inherent cells. Then function of inherent cells can be recovered gradually.
Thirdly, repair injured inherent cells, supply requested substances for cell recover and activate the kidney self-repair function.
The reason why Polycystic Kidney Disease patients have higher serum creatinine is that patients’ cysts growing bigger gradually, which canl damage renal inherent cells, start the process of renal fibrosis and aggravate inherent cells injury furthrt. Damaged inherent cells can shrink blood vessel, which can cause High Blood Pressure. Because epithelial cells in inherent cells get damaged, they can’t prevent blood protein leakage,and then Albuminuria occurs. When inherent cells are so injured that they can not excrete more toxins, serum creatinine increases.
Ⅱ.What is the key point of causing Polycystic Kidney Disease?
Inherent cells injury caused by renal fibrosis is the real cause of Polycystic Kidney Disease. High Blood Pressure, Proteinuria, Blood Urine caused by inherent cells injury are symptoms of this disease. If patients want to cure High Blood Pressure, Proteinuria, Blood Urine, they need to cure real cause of this disease firstly.
No matter what kinds of therapeutic methods are taken, real cause of Polycystic Kidney Disease should be treated firstly. Treating disease must block Renal Fibrosis which can damage renal inherent cells. As long as the process of renal fibrosis is blocked and damaged inherent cells get repaired, symptoms of Albuminuria and Haematuria can disappear and cysts can be shrunk gradually.
The reason why disease continues for a long term is that effective treatment is not taken to block Renal Fibrosis.So the real reason why disease can’t be cured is that medicine can’t prevent the renal fibrosis from damaging renal inherent cells.
Ⅲ.How to treat Polycystic Kidney effectively?
Firstly, illness condition caused by renal inherent cells injury should be controlled firstly.
Secondly, taking proper treatment to reduce cyst fluid can relieve further pressure on renal inherent cells. Then function of inherent cells can be recovered gradually.
Thirdly, repair injured inherent cells, supply requested substances for cell recover and activate the kidney self-repair function.
2016年9月24日星期六
Symptoms Caused by Polycystic Kidney Disease
Most PKD patients do not have clinical symptoms in the early stage. While in
end stage, due to cysts as well as increasing cyst internal pressure and
infections, most patients can get the following symptoms:
1. Albuminuria: generally, protein content in urine is tiny, no more than 2g each 24 hours. Nephrotic Syndrome seldom occurs.
2. Abdominal masses: this is also the main reason why patients do to hospital for a check. Enlarged kidneys can be touched among 60% to 80% PKD patients. Normally, the larger kidneys are, the lower renal function is.
3. High Blood Pressure: cysts compress kidneys, which can lead to renal ischemia and increase renin secretion, causing High Blood Pressure. When renal function is normal, more than 50% patients can get High Blood Pressure. This number can be much higher when renal function declines.
4. Haematuria: this symptoms can be expressed by microscopic Haematuria and gross Haematuria, occurs periodically. Patients usually feel really painful when Haematuria appears, and this pain can be more serious after strenuous exercise, trauma and infection. There are a large amount of arteries under cyst wall. Due to growing pressure or complicated infection, blood vessel of cyst wall can bleed for excessive tensility.
5. Renal function decline: growing cysts will replace and compress normal renal tissue, which can reduce healthy renal tissue obviously, causing progressive decline of renal function.
6. Pain or discomfort on waist and abdomen: kidney enlargement can increase tensility of renal capsule. Besides, more cysts in kidneys can increase water content of kidneys, which can make kidney heavier, leading waist pain.
1. Albuminuria: generally, protein content in urine is tiny, no more than 2g each 24 hours. Nephrotic Syndrome seldom occurs.
2. Abdominal masses: this is also the main reason why patients do to hospital for a check. Enlarged kidneys can be touched among 60% to 80% PKD patients. Normally, the larger kidneys are, the lower renal function is.
3. High Blood Pressure: cysts compress kidneys, which can lead to renal ischemia and increase renin secretion, causing High Blood Pressure. When renal function is normal, more than 50% patients can get High Blood Pressure. This number can be much higher when renal function declines.
4. Haematuria: this symptoms can be expressed by microscopic Haematuria and gross Haematuria, occurs periodically. Patients usually feel really painful when Haematuria appears, and this pain can be more serious after strenuous exercise, trauma and infection. There are a large amount of arteries under cyst wall. Due to growing pressure or complicated infection, blood vessel of cyst wall can bleed for excessive tensility.
5. Renal function decline: growing cysts will replace and compress normal renal tissue, which can reduce healthy renal tissue obviously, causing progressive decline of renal function.
6. Pain or discomfort on waist and abdomen: kidney enlargement can increase tensility of renal capsule. Besides, more cysts in kidneys can increase water content of kidneys, which can make kidney heavier, leading waist pain.
2016年9月21日星期三
Can Season Affect PKD Illness Condition
In spring, everything has a new life, and this is a season favorable for
Kidney Disease patients’ recovery. But there is too much wind in spring, which
is easy to cause wind-pathogen. In hot summer, patients are easy to be injured
by fire-pathogen. Besides, it is hot and wet in summer and heat or dampness can
also damage human body. Autumn is really dry, so patients should care about
dryness which can damage Yin of lung and kidney. Winter is cold, which can make
Kidney Disease patients get Yang injury easily.
From clinical viewpoint, the hottest and coldest seasons are both unfavorable for patients’ illness condition. Hot weather is easy to cause various infections like urinary tract infection, gastrointestinal tract infection and upper respiratory tract infection and so on, all of which can speed up the development of PKD illness condition directly or indirectly. PKD patients, especially patients in third or fourth stage, usually have much lower immunity. They are easy to catch a cold, which can not only worsen PKD illness condition, but also affect blood pressure condition.
Specialists on Kidney Disease note that: as for PKD patients, the best treating timings are spring and autumn, which can reduce disadvantages existing in summer and winter.
Besides, infectious disease may occur in each season, so PKD patients should pay more attention in order to prevent infections and colds and so on. This can decrease the chance of damaging kidney.
The key of treating PKD is to block Renal Fibrosis, repair injured renal inherent cells and protect remained renal function. Micro-Chinese Medicine is suggested to treat Polycystic Kidney Disease. It has been improved by clinical practices that this treatment has a good effect on treating PKD and this treatment can treat PKD by blocking Renal Fibrosis, prolonging patients’ life greatly.
From clinical viewpoint, the hottest and coldest seasons are both unfavorable for patients’ illness condition. Hot weather is easy to cause various infections like urinary tract infection, gastrointestinal tract infection and upper respiratory tract infection and so on, all of which can speed up the development of PKD illness condition directly or indirectly. PKD patients, especially patients in third or fourth stage, usually have much lower immunity. They are easy to catch a cold, which can not only worsen PKD illness condition, but also affect blood pressure condition.
Specialists on Kidney Disease note that: as for PKD patients, the best treating timings are spring and autumn, which can reduce disadvantages existing in summer and winter.
Besides, infectious disease may occur in each season, so PKD patients should pay more attention in order to prevent infections and colds and so on. This can decrease the chance of damaging kidney.
The key of treating PKD is to block Renal Fibrosis, repair injured renal inherent cells and protect remained renal function. Micro-Chinese Medicine is suggested to treat Polycystic Kidney Disease. It has been improved by clinical practices that this treatment has a good effect on treating PKD and this treatment can treat PKD by blocking Renal Fibrosis, prolonging patients’ life greatly.
2016年9月19日星期一
How to Diagnose Polycystic Kidney Disease
Polycystic Kidney Disease is a kind of familial hereditary disease.
Sometimes, each family member has this disease. Early diagnosis is very
important to treat Polycystic Kidney Disease which always occurs with symptoms
of Haematuria, High Blood Pressure and abdominal masses, etc. But only through
these symptoms, we can not get an exact diagnosis of Polycystic Kidney Disease.
Instead, exact diagnosis should be made after normal examinations.
Ⅰ. Laboratory Examination:
Firstly, routine urine test: no abnormality can be found in early stage and microscopic Haematuria can be found in middle and late stages. Some patients may get Albuminuria, and White Blood Cells and pyocyte can be found if there is stone or infection at the same time.
Secondly, urine osmotic pressure declines in the early stage, which may be caused by less renal sensitivity of diuretic. With renal function aggravation, renal concentrating function is damaged and osmotic pressure declines further.
Thirdly, serum creatinine and urea nitrogen increases with worsening Renal Insufficiency and Renal Failure.
Ⅱ. Imaging Examination:
Firstly, CT examination has a correct rate of more than 90% on Polycystic Kidney Disease diagnosis. Through CT examination, cysts can be seen with obvious boundary to renal parenchyma and bilateral kidneys change their normal shape. Besides, complicated cysts in liver and spleen can also be found by CT examination.
Secondly, MRI is beneficial to define cyst fluid composition. When cyst internal bleeding happens, hemoglobin can be degraded and ferrous iron reduces to ferric iron which has paramagnetic characteristic, leading to abnormal signal.
Thirdly, X-Ray abdominal plain film shows enlarged kidney shape. IVP test is expressed by renal pelvis and renal calices malformation in strange spiderlike shape.
Fourthly, Type-B Ultrasonic examination is the first choice to diagnose Polycystic Kidney Disease presently. Through Type-B Ultrasonic, typical expression of cysts is no echo areas with various sizes in bilateral kidneys. Cyst wall is not clear, but with strong echo. Cysts are in round or oval shape. Complex masses can be found through Type-B Ultrasonic examination if this disease is complicated with cyst internal bleeding, stone and calcification, etc.
When Polycystic Kidney Disease develops into some certain degree, it is not difficult to make a clinical diagnosis based on irregular bilateral kidneys enlargement, various sizes of cysts in bilateral kidneys through Type-B Ultrasonic examination, CT and other imaging examinations, as well as patients family history.
Once patients are diagnosed as Polycystic Kidney Disease, they should accept treatment actively in order to delay illness condition developing and prevent Polycystic Kidney Disease developing into Renal Failure and Uremia.
Ⅰ. Laboratory Examination:
Firstly, routine urine test: no abnormality can be found in early stage and microscopic Haematuria can be found in middle and late stages. Some patients may get Albuminuria, and White Blood Cells and pyocyte can be found if there is stone or infection at the same time.
Secondly, urine osmotic pressure declines in the early stage, which may be caused by less renal sensitivity of diuretic. With renal function aggravation, renal concentrating function is damaged and osmotic pressure declines further.
Thirdly, serum creatinine and urea nitrogen increases with worsening Renal Insufficiency and Renal Failure.
Ⅱ. Imaging Examination:
Firstly, CT examination has a correct rate of more than 90% on Polycystic Kidney Disease diagnosis. Through CT examination, cysts can be seen with obvious boundary to renal parenchyma and bilateral kidneys change their normal shape. Besides, complicated cysts in liver and spleen can also be found by CT examination.
Secondly, MRI is beneficial to define cyst fluid composition. When cyst internal bleeding happens, hemoglobin can be degraded and ferrous iron reduces to ferric iron which has paramagnetic characteristic, leading to abnormal signal.
Thirdly, X-Ray abdominal plain film shows enlarged kidney shape. IVP test is expressed by renal pelvis and renal calices malformation in strange spiderlike shape.
Fourthly, Type-B Ultrasonic examination is the first choice to diagnose Polycystic Kidney Disease presently. Through Type-B Ultrasonic, typical expression of cysts is no echo areas with various sizes in bilateral kidneys. Cyst wall is not clear, but with strong echo. Cysts are in round or oval shape. Complex masses can be found through Type-B Ultrasonic examination if this disease is complicated with cyst internal bleeding, stone and calcification, etc.
When Polycystic Kidney Disease develops into some certain degree, it is not difficult to make a clinical diagnosis based on irregular bilateral kidneys enlargement, various sizes of cysts in bilateral kidneys through Type-B Ultrasonic examination, CT and other imaging examinations, as well as patients family history.
Once patients are diagnosed as Polycystic Kidney Disease, they should accept treatment actively in order to delay illness condition developing and prevent Polycystic Kidney Disease developing into Renal Failure and Uremia.
2016年9月16日星期五
Process of Polycystic Kidney Disease Developing into Uremia
It is a slow developing process from Polycystic Kidney Disease to Uremia.
Growing and increasing cysts are root cause of leading to Uremia. In the early
stage, there are very few cysts in kidney, and cyst number increases with
illness development. Finally, healthy kidney can be filled with massive cysts,
resulting in High Blood Pressure and renal functional abnormality. Then Uremia
occurs naturally.
There are five stages in the process of Polycystic Kidney Disease developing into Uremia:
StageⅠ. Polycystic Kidney Disease Occurring Stage:
Polycystic Kidney Disease is a kind of hereditary disease. Patients were born with smaller cysts which are difficult to be found. Generally, this disease can not be found before patients are 20 years old. If there is Polycystic Kidney Disease patient in one family, other family members should go to hospital for a check as early as possible in order to observe cysts growing condition in time. Besides, patients should care more about their daily life in this stage.
Stage Ⅱ. Growing Stage:
When patients are in the age range of 30 to 40 years old, cysts grow faster than the first stage. In this stage, close observation is necessary. Western Medicine has no effective way to treat this disease and holds the opinion that there is no need to treat the disease in this stage. Actually, patients still need active treatment in this stage with the purpose to stop or delay cysts growing through applying Chinese Medicine with strong function of activating blood and eliminating blood stasis. Through this way, patients’ life can be prolonged greatly. In a sense, this stage is the key stage for Micro-Chinese Medicine to delay cysts growth.
Stage Ⅲ. Cyst Swollen Stage:
After patients are 40 years old, cysts can have a further growth and enlargement. With cysts growing, more clinical symptoms, like waist pain, Albuminuria, Haematuria, High Blood Pressure, appear. As for treatment, this stage is a very important stage for the treatment of Chinese Medicine combined with Western Medicine to play its role in treating Polycystic Kidney Disease.
Stage Ⅳ. Cyst Rupture Stage:
If cysts grow continuously, cyst rupture happens under the action of some external factors. Once cyst rupture happens, patients should be sent to hospital for treatment as soon as possible in order to control infection, prevent Hematosepsis and acute renal function aggravation, which is beneficial to solve other symptoms.
StageⅤ. Uremia Stage:
Polycystic Kidney Disease is a kind of hereditary disease, which means that normal renal tissue is replaced by cysts with fluid inside. When these cysts grow bigger, they will lead to kidney functional abnormality, causing difficulty for kidney to play its normal role in excreting metabolism waste. With illness condition development, renal function is so damaged and Uremia happens. As for treatment of Uremia, the key is to block Renal Fibrosis.
From the above, we can see that it is a very slow process of Polycystic Kidney Disease developing into Uremia. Though Polycystic Kidney Disease can not be eliminate from its root, it can be controlled effectively if proper treatment can be taken to block Renal Fibrosis, which is helpful to prevent PKD developing into Uremia.
There are five stages in the process of Polycystic Kidney Disease developing into Uremia:
StageⅠ. Polycystic Kidney Disease Occurring Stage:
Polycystic Kidney Disease is a kind of hereditary disease. Patients were born with smaller cysts which are difficult to be found. Generally, this disease can not be found before patients are 20 years old. If there is Polycystic Kidney Disease patient in one family, other family members should go to hospital for a check as early as possible in order to observe cysts growing condition in time. Besides, patients should care more about their daily life in this stage.
Stage Ⅱ. Growing Stage:
When patients are in the age range of 30 to 40 years old, cysts grow faster than the first stage. In this stage, close observation is necessary. Western Medicine has no effective way to treat this disease and holds the opinion that there is no need to treat the disease in this stage. Actually, patients still need active treatment in this stage with the purpose to stop or delay cysts growing through applying Chinese Medicine with strong function of activating blood and eliminating blood stasis. Through this way, patients’ life can be prolonged greatly. In a sense, this stage is the key stage for Micro-Chinese Medicine to delay cysts growth.
Stage Ⅲ. Cyst Swollen Stage:
After patients are 40 years old, cysts can have a further growth and enlargement. With cysts growing, more clinical symptoms, like waist pain, Albuminuria, Haematuria, High Blood Pressure, appear. As for treatment, this stage is a very important stage for the treatment of Chinese Medicine combined with Western Medicine to play its role in treating Polycystic Kidney Disease.
Stage Ⅳ. Cyst Rupture Stage:
If cysts grow continuously, cyst rupture happens under the action of some external factors. Once cyst rupture happens, patients should be sent to hospital for treatment as soon as possible in order to control infection, prevent Hematosepsis and acute renal function aggravation, which is beneficial to solve other symptoms.
StageⅤ. Uremia Stage:
Polycystic Kidney Disease is a kind of hereditary disease, which means that normal renal tissue is replaced by cysts with fluid inside. When these cysts grow bigger, they will lead to kidney functional abnormality, causing difficulty for kidney to play its normal role in excreting metabolism waste. With illness condition development, renal function is so damaged and Uremia happens. As for treatment of Uremia, the key is to block Renal Fibrosis.
From the above, we can see that it is a very slow process of Polycystic Kidney Disease developing into Uremia. Though Polycystic Kidney Disease can not be eliminate from its root, it can be controlled effectively if proper treatment can be taken to block Renal Fibrosis, which is helpful to prevent PKD developing into Uremia.
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