What are the types of FSGS kidney disease?
Primary and secondary Focal Segmental Glomerulosclerosis are the two types. In primary, the disease could develop as an isolated kidney disease, while in secondary, the disease can be caused by other reasons.
Why isn’t dialysis or kidney transplantation the best choice?
Dialysis and kidney transplantation have certain disadvantages and make them not the best choices. Dialysis brings with certain side-effects and has no good to boost one’s kidney function. To make things worse, it contributes to worsen one’s remaining kidney function because patients with ESRD would rely too much on dialysis and abandon his remaining function. Since we have already known the reason of dialysis, how about kidney transplantation?
Patients with FSGS kidney disease are not the best candidates to perform transplantation. Why? This is because those patients suffer from a high recurrence rate even after the surgery. The specific reason of high recurrence rate is unexplained, but it is believed that the disease is sort of connected with abnormal immune system and immune complexes. The primary disease would come back again even if the surgery is done.
Why is Immunotherapy better than those two conventional treatments?
Immunotherapy is not just one single treatment; instead, it is a combo of multiple treatments, which can boost the therapeutic effects as much as possible. Most importantly, Immunotherapy treats the disease from its root cause—the abnormal immune system, immune complexes and overactive inflammatory reaction.
Since Focal Segmental Glomerulosclerosis is proven to be an immune kidney disease, then IgM and C3 alexin can be found by immunofluorescence. Some may ask what are IgM and C3. Those two are immune complexes deposit in kidneys and trigger overactive inflammatory reaction. The disease can be treated completely only if immune complexes and immune system are cleared out or corrected.
Why dialysis and kidney transplantation fail?
Dialysis could just remove micro-molecules but couldn’t discharge IgM and C3 from blood. The transplantation, on the other hand, just replace kidney without clearing those harmful substances out, which explains why most patients with FSGS would suffer from recurring.
Immunotherapy obtains not just scientific tests, but advanced blood purification technique. On the basis of a right lab results, blood purification will be given subsequently, which is good for further treatments.
