Symptoms in Late Stage of Polycystic Kidney Disease

In the early stage of Polycystic Kidneys Stage, patients' kidneys are usually in a normal size, and patients do not have obvious discomfort normally. While in the late stage of Polycystic Kidney Disease, with cysts growing, kidney size can also increase with morphological abnormality which may includes abnormality of renal calices and renal pelvis, damage to integrate structure of renal papilla and renal pyramid. Cysts are round with different sizes.

At the beginning, only a few cysts can be seen in kidney. With illness condition development, cysts become more and more, and finally they can replace renal tissue. At this moment, Kidney can grow to the size of about two football. Through microscope, integrate renal structure can be seen between cysts. But these renal structures are found with changes from normal tissue to Glomerular Sclerosis, renal tubule atrophy, or interstitial fibrosis and other changes. All these changes were caused by renal ischemia under cystic pressure.

Bilateral Kidneys of Patients who suffer from Polycystic Kidney Disease can have an obvious increase on size and weight, about 10 times more than normal ones. Epithelial cells become columnar and are in conformity with collecting tubes. Renal calices and renal pelvis are narrowed and minified due to swollen renal parenchyma.

At last, renal function can be completely damaged with the growing cysts on polycystic kidney, and then Renal Insufficiency, or even Uremia can be caused, with losing renal function.

Learn More: Can Chinese Medicine Treat Polycystic Kidney Disease (PKD)