Glomerulosclerosis refers to scarring or hardening of the glomeruli -- blood vessels located in the kidneys. The glomeruli filter the blood as it passes through the kidneys. They remove waste fluids that then leave the body as urine.
The etiology of FSGS can have a major influence on therapeutic decision-making. The etiologic hallmark of primary idiopathic FSGS is podocyte injury while secondary types of FSGS (e.g., familial-genetic types, virus-associated FSGS, unilateral renal agenesis, and FSGS associated with renal dysplasia, surgical renal ablation, hypertension, and obesity) develop as a maladaptive response to glomerular “overwork.” The characteristic features of primary idiopathic FSGS include extensive foot process effacement, variable glomerulomegaly, and a clinical presentation consistent with full-blown nephrotic syndrome.
a new treatment immunotherapy is recommended which is available in China.
What is immunotherapy?
Immunotherapy is a comprehensive therapy which is created based on the theory of immunology. It is though that 95% kidney disease including FSGS is caused by the disorder of immune system, meaning the disorder of immune system leads to foreign substances attack the body and if it destroys the kidneys, it is more likely to cause kidney disease. The destroyed part of kidney determines the type of kidney disease.Immunotherapy is characterized by treating FSGS step by step from the accurate diagnosis, treatment and follow-up. It aims to restore kidney and treat FSGS by improving and rebuild the immune system.
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