Normally, serum creatinine is not affected by external factors like diet,
high catabolism and so on. On the condition that exogenous creatinine intake is
steady and internal generation is constant, concentration of serum creatinine
mostly depend on Glomerular filtrating rate. However, serum creatinine is not
equal to creatinine clearance rate which is more sensitive than the former one.
During renal function compensatory stage, creatinine clearance rate reduces but
serum creatinine is normal. Only if glomerular filtrating rate decreases to less
than 50%, serum creatinine will increase rapidly. Therefore, when serum
creatinine is obviously higher than normal condition, renal function has already
been damaged greatly. Because creatinine clearance rate is still related with
glomerular concentrated function, serum creatinine is a significant index to
reflect glomerular function once renal concentrated function in injured.
Normally, serum creatinine value of male should be in the range of 53 to
106gmol/L or 0.6 to 1.2rug/d1, and female value should be 44.2 to 97.2gmol/L or
0.5 to 1.1rug/d1. Because internal generation of creatinine is related with
muscle amount, serum creatinine value of people with well-developed muscle may
be high to 130gmol/L, while for very thin people, creatinine value may be only
26.5gmol/L. if patients serum creatinine is higher than 132gmol/L, their
glomerular function may have been greatly damaged. Besides emaciation, due to
the assimilation of increased glomerular filtrating rate and fetus, people who
are pregnant usually have a lower serum creatinine value than normal person.
Normally, very tiny creatinine is secreted by renal tubule, and some may
diffuse into enteric cavity. As for Uremia patients, renal tubule secretion
increases greatly, with 16% to 60% creatinine entering into enteric cavity.
Reproduction of streptococcus and enterococcus in upper gastrointestinal tract
can produce creatinine lyase which can degrade creatinine. For this reason, as
for some Uremia patients, concentration of serum creatinine and urine creatinine
as well as internal creatinine clearance rate may fluctuate.
2016年10月5日星期三
2016年7月12日星期二
Causes of High Level of Serum Creatinine
What are the causes of high level of serum creatinine? Creatinine is the
metabolic productions of muscle in human body and 20g muscle can generate 1mg
creatinine. Creatinine can be divided into serum creatinine (Scr) and urine
creatinine (Ucr). The creatinine is filtrated by glomerulus(the important
components of kidney) to eliminate out of human body. There are two sources of
Scr, one is the metabolic products of meat food in human body, the other one is
the metabolic products of muscle in human body. When you have a stable intake of
meat food and the metabolic products of muscle are stable, the level of
creatinine won't change much. As for Ucr, it is the creatinine eliminated by the
urine after the filtration of glomerulus.
So what are the causes of the high level of serum creatinine? The patients of kidney disease have the fluctuation of creatinine in clinical examinations. The manifestation is that Scr is higher while the Ucr is lower.
The causes of the high level of Scr is complex. After the renal damage caused by various pathogenesis, the shape of damaged renal inherent cells will change and they will form the pathological change, which will stimulate the renal fibroblasts to turn into muscle fibroblasts and stimulate the normal inherent renal structure to form the same pathological change. Then the pathological change expands form one unit to the whole kidney, from local to the whole, then the damage develops into the renal damage period. At this time, for the continuous damage of kidney, the renal function of eliminating waste will decrease, which will cause the accumulation of creatinine and other toxin in human body, then the Scr and BUN increase but Ucr decreases, at the same time the glomerulus filtration rate decreases.
The increase of Scr is an important clinical symptom of kidney disease, on the other hand, the accumulation of Scr in human body will damage the kidney and other organs in return. Therefor, we must adopt effective methods to control the level of creatinine positively. However, the basic method should proceed with the pathogenesis of kidney disease and treat the kidney disease fundamentally. As for the treatment of kidney disease, at present, the most effective treatment of PKD is combining traditional Chinese medicine with Western medicine. Now a brand new therapy has been developed out by Shijiazhuang Kidney Disease Hospital-- Micro-Chinese Medicine Osmotherapy. This therapy adopts the most advanced technology in the world to micronize the traditional Chinese medicine into medicine powder,which has strong ability of permeability and can access to kidney directly by external application. By this method, the effects of Chinese medicine can be accelerated and enhanced. Besides, combining with Western medicine, this therapy has achieved rather good effects in clinical. If you have any other questions or want to learn more about Micro-Chinese Medicine Osmotherapy, please contact our experts on-line.
So what are the causes of the high level of serum creatinine? The patients of kidney disease have the fluctuation of creatinine in clinical examinations. The manifestation is that Scr is higher while the Ucr is lower.
The causes of the high level of Scr is complex. After the renal damage caused by various pathogenesis, the shape of damaged renal inherent cells will change and they will form the pathological change, which will stimulate the renal fibroblasts to turn into muscle fibroblasts and stimulate the normal inherent renal structure to form the same pathological change. Then the pathological change expands form one unit to the whole kidney, from local to the whole, then the damage develops into the renal damage period. At this time, for the continuous damage of kidney, the renal function of eliminating waste will decrease, which will cause the accumulation of creatinine and other toxin in human body, then the Scr and BUN increase but Ucr decreases, at the same time the glomerulus filtration rate decreases.
The increase of Scr is an important clinical symptom of kidney disease, on the other hand, the accumulation of Scr in human body will damage the kidney and other organs in return. Therefor, we must adopt effective methods to control the level of creatinine positively. However, the basic method should proceed with the pathogenesis of kidney disease and treat the kidney disease fundamentally. As for the treatment of kidney disease, at present, the most effective treatment of PKD is combining traditional Chinese medicine with Western medicine. Now a brand new therapy has been developed out by Shijiazhuang Kidney Disease Hospital-- Micro-Chinese Medicine Osmotherapy. This therapy adopts the most advanced technology in the world to micronize the traditional Chinese medicine into medicine powder,which has strong ability of permeability and can access to kidney directly by external application. By this method, the effects of Chinese medicine can be accelerated and enhanced. Besides, combining with Western medicine, this therapy has achieved rather good effects in clinical. If you have any other questions or want to learn more about Micro-Chinese Medicine Osmotherapy, please contact our experts on-line.
2016年3月20日星期日
Creatinine Levels in Blood (Serum Creatinine)
Creatinine in blood is also called serum creatinine. It is a chemical waste
molecule that is generated from muscle metabolism. Therefore it is closely
related to the amount of muscles. It will not easily affected by diet. A
minority of creatinine in blood comes from protein that people have eaten, which
do not affect creatinine in blood greatly. Creatinine in blood is one of the
important clinical indicators of renal function.
What does it indicate if creatinine level is high in blood?
Creatinine level in blood indicates the degree of kidney parenchyma damage clearly, but it is not a sensitive indicator. It is due to the reason that creatinine level in blood begins to decline when GFR decreases to one-third of normal people’s. Then creatinine level in blood will increase. Kidneys have strong metabolic capacity. This is why people will not have feelings about it when damage of kidney function is not serious.
What are the reasons of increase of creatinine level in blood?
1. Fatigue can cause temporary increase of creatinine level in blood.
2. If concurrent infection including cold, pneumonia, intestinal tract infection and urinary tract infection presents in people with renal dysfunction, creatinine level in blood can increase in short time.
3. Body loses more water can be one of the causes. Fever, little water intake will cause pachemia when you are in diuretic phase. Reducing of blood flow volume of kidney could cause increase of creatinine level in blood.
4. People with kidney diseases take some medication that is toxic to kidney. Creatinine level in blood can increase and sometimes it can not be reversed.
5. The relapse of kidney diseases, Oliguria even anuria may present, acute renal dysfunction can be accompanied. Then creatinine level in blood can increase.
6. If there is hypertension, creatinine level in blood can increase gradually if your blood pressure is not controlled well and moderate or large quantity of proteinuria (urine protein is more than 1 gram or even 1.5 gram) presents for a long time.
If your creatinine level in blood has increased, don't panic, sometimes it will decrease itself. But it is better to have a physical examination and get the diagnosis in time. In some cases, timly treatment of high level of creatinine in blood is suggested to prevent serious conditions.
What does it indicate if creatinine level is high in blood?
Creatinine level in blood indicates the degree of kidney parenchyma damage clearly, but it is not a sensitive indicator. It is due to the reason that creatinine level in blood begins to decline when GFR decreases to one-third of normal people’s. Then creatinine level in blood will increase. Kidneys have strong metabolic capacity. This is why people will not have feelings about it when damage of kidney function is not serious.
What are the reasons of increase of creatinine level in blood?
1. Fatigue can cause temporary increase of creatinine level in blood.
2. If concurrent infection including cold, pneumonia, intestinal tract infection and urinary tract infection presents in people with renal dysfunction, creatinine level in blood can increase in short time.
3. Body loses more water can be one of the causes. Fever, little water intake will cause pachemia when you are in diuretic phase. Reducing of blood flow volume of kidney could cause increase of creatinine level in blood.
4. People with kidney diseases take some medication that is toxic to kidney. Creatinine level in blood can increase and sometimes it can not be reversed.
5. The relapse of kidney diseases, Oliguria even anuria may present, acute renal dysfunction can be accompanied. Then creatinine level in blood can increase.
6. If there is hypertension, creatinine level in blood can increase gradually if your blood pressure is not controlled well and moderate or large quantity of proteinuria (urine protein is more than 1 gram or even 1.5 gram) presents for a long time.
If your creatinine level in blood has increased, don't panic, sometimes it will decrease itself. But it is better to have a physical examination and get the diagnosis in time. In some cases, timly treatment of high level of creatinine in blood is suggested to prevent serious conditions.
2015年12月3日星期四
What Is A Dangerous Creatinine Level When to Need Dialysis
Serum Creatinine is an important index of calculating kidney function. As
kidney function declines, the creatinine level will rise thereby. Serum
creatinine will not elevate until the kidneys are damaged more than 50%. Then,
what is a dangerous creatinine level when to need dialysis?
In fact, dialysis is only a substitutive therapy, it can not deal with kidney problems from root. Some patients begin to have dialysis when the serum creatinine level reaches 400-500umol/L. While, some patients might not receive dialysis until the serum creatinine level is up to 1000umol/L. Generally, patients with kidney problems secondary to Diabetes start dialysis earlier than others. That is to say, it is your specific condition that decides when you start to have dialysis. And, patients start to dialysis when the serum creatinine level is 425umol/L in the western countries. While in China, the creatinine level is 707umol/L.
Indeed, dialysis can reduce serum creatinine in a very short time. However, dialysis can do nothing to repair kidney function. If the serum creatinine level is high, patients should receive a natural treatment to get the kidney function repaired. The treatment of kidney function needs a long time, during which patients should try not to get a cold. Besides, strictly control your diet; do not overtired; keep blood pressure and blood sugar under control. If patients can pay attention to these factors, serum creatinine can go down naturally.
In fact, dialysis is only a substitutive therapy, it can not deal with kidney problems from root. Some patients begin to have dialysis when the serum creatinine level reaches 400-500umol/L. While, some patients might not receive dialysis until the serum creatinine level is up to 1000umol/L. Generally, patients with kidney problems secondary to Diabetes start dialysis earlier than others. That is to say, it is your specific condition that decides when you start to have dialysis. And, patients start to dialysis when the serum creatinine level is 425umol/L in the western countries. While in China, the creatinine level is 707umol/L.
Indeed, dialysis can reduce serum creatinine in a very short time. However, dialysis can do nothing to repair kidney function. If the serum creatinine level is high, patients should receive a natural treatment to get the kidney function repaired. The treatment of kidney function needs a long time, during which patients should try not to get a cold. Besides, strictly control your diet; do not overtired; keep blood pressure and blood sugar under control. If patients can pay attention to these factors, serum creatinine can go down naturally.
2014年12月17日星期三
Creatinine renal disease patients should understand the knowledge
Creatinine (creatinine, Cr) protucdo muscle is metabolized in the human body. Each 20g muscula metabolism can cause 1mg creatinine. Creatinine main rule out the glomerular filtration body. Serum creatinine is two typical exogenous and endogenous. exogenous creatinine is the meat food product after metabolism. endogenous creatinine is metabolize muscle organization products. When stable food meat consumption, there is no change in muscle metabolism. creatinine can cause stable.
When renal function not good creatinine body seconverte in harmful toxin buildup. Plasma creatinine normarmente upper limit is about 100mol / l. Besides hospitals different test standards are different, but can not exceder120mol / l. In time nephron in the number of ml of plasma endogenous creatinine cleaning is called endogenous creatinine clearance (C cr) .Prueba of endogenous creatinine clearance may reflect glomerular filtration rate and effective canditad estimate nephron, why is proof the quantitative determination of kidney damage. Because this mode of easy operation, less interference factor, no higher sensitivity in each experiment seconverte commonly used in the major clinical renal function.
Density changing serum creatinine determined by the rate of glomerular filtration. When the capacity of low leakage, then the density of creatinine rises. If the amount of serum creatinine greater than normal amount, means being hurt by the kidney, serum creatinine can inform the situation exactly being injured kidney, it is not sensitive target. Because when the rate of glomerular filtration down to third man normal, serum creatinine rises only clearly. So because the capacity of metabolism is very strong, when the kidney is hurt less damage, most people do not feel bad, because when many people feel nausea, vomiting, merearse, your kidneys were seriously wounded, now creatinine rises clearly.
No matter serum creatinine is low or serum creatinine is high, patients have to take seriously. Creatinine is produced metabolized in the muscle body, creatinine body discharge outside kidney. Generally the amount of muscle that is stable, so the amount of creatinine production is stable, the serum creatinine level depends on the amount of creatinine mainly discharging. The compensatory kidney function is very strong, if two kidneys both are normal, it only deploys kidney function, serum creatinine can maintain normal. So when kidneys levels have hurt accounted for more than half, can cause serum creatinine rises. Therefore, serum creatinine may not reflect early and mild low kidney function.
For more information about creatinine, or condition you have any questions, please contact our master online, please or give us a message in the following article, we will within 24 hours to give a professional response.
When renal function not good creatinine body seconverte in harmful toxin buildup. Plasma creatinine normarmente upper limit is about 100mol / l. Besides hospitals different test standards are different, but can not exceder120mol / l. In time nephron in the number of ml of plasma endogenous creatinine cleaning is called endogenous creatinine clearance (C cr) .Prueba of endogenous creatinine clearance may reflect glomerular filtration rate and effective canditad estimate nephron, why is proof the quantitative determination of kidney damage. Because this mode of easy operation, less interference factor, no higher sensitivity in each experiment seconverte commonly used in the major clinical renal function.
Density changing serum creatinine determined by the rate of glomerular filtration. When the capacity of low leakage, then the density of creatinine rises. If the amount of serum creatinine greater than normal amount, means being hurt by the kidney, serum creatinine can inform the situation exactly being injured kidney, it is not sensitive target. Because when the rate of glomerular filtration down to third man normal, serum creatinine rises only clearly. So because the capacity of metabolism is very strong, when the kidney is hurt less damage, most people do not feel bad, because when many people feel nausea, vomiting, merearse, your kidneys were seriously wounded, now creatinine rises clearly.
No matter serum creatinine is low or serum creatinine is high, patients have to take seriously. Creatinine is produced metabolized in the muscle body, creatinine body discharge outside kidney. Generally the amount of muscle that is stable, so the amount of creatinine production is stable, the serum creatinine level depends on the amount of creatinine mainly discharging. The compensatory kidney function is very strong, if two kidneys both are normal, it only deploys kidney function, serum creatinine can maintain normal. So when kidneys levels have hurt accounted for more than half, can cause serum creatinine rises. Therefore, serum creatinine may not reflect early and mild low kidney function.
For more information about creatinine, or condition you have any questions, please contact our master online, please or give us a message in the following article, we will within 24 hours to give a professional response.
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