PKD (Polycystic Kidney Disease) is characterized by its familial aggregation.
It belongs to genetic kidney disease that numerous cysts are formed in renal
cortex and renal medulla. However, besides congenital factors, various acquired
factors can lead to PKD (Polycystic Kidney Disease). Please read on to know more
details about the pathogenesis of PKD (Polycystic Kidney Disease).
1. Congenital factors
Generally speaking, the congenital factor is refers to the faulty genes which
can be on the 16th chromosome, or on the 4th chromosome seldom. As for ADPKD
(autosomal dominant Polycystic Kidney Disease), if one parent carries the faulty
gene, his or her children have a 50% chance to get it. So, most patients with
PKD have family history.
2. Acquired factors
Infections: various infections can lead to disorders in the internal
environment, which will trigger the gene mutation. As a result, the cysts will
be formed.
Additionally, infections on any part of the body will go to kidneys
and cause damage.
Toxins: with too many toxins building up in the body can be a main reason of
gene mutation and dysplasia. The common toxins can be agricultural chemicals,
radiation and polluted foods. Worse than that, some medicines are toxins to
drugs, leading to renal injury.
From the above introduction, we have must have certain knowledge that PKD is
the combined result of congenital factors and acquired factors. Since we can not
change the gene problem, we can do something to avoid the acquired factors.
At last, no matter which kind of factors lead to your Polycystic Kidney
Disease, timely treatment is necessary. Sincerely hope everyone with PKD
problems can get better soon.
