Is it Good for Patients with High or Low Creatinine

Creatinine is the metabolic product of muscle, and every 20g muscle metabolism will produce 1 mg creatinine. Creatinine is filtrated mainly by the glomerulus. Blood creatinine has exogenous creatinine and endogenous creatinine, the former one is the metabolic product of meat in the body, the latter one is the metabolic product of muscular tissue in the body. With stable meat intake and muscle metabolism, the generation of creatinine will stable.
High serum creatinine means that the kidney function has damaged, the ability of discharging waste has decreased, and some harmful toxins can’t discharge out of body. Why patients have low-creatinine?
Low serum creatinine refers to kidney get invaded by various pathogenesis, the damaged renal inherent cells have phenotype transformation, which stimulates the kidney fibroblast turns into myofibroblast. Furthermore, it stimulates the inherent normal renal tissues to occur the same pathology, thus kidney become more and more week, kidney go into the implement qualitative damage period(that is renal damage period ).At this time, because the kidney get damaged continuously, the function of secreting is decreased, then toxic substance such as creatinine etc accumulate in the body, increase the symptoms of increasing Serum Creatinine and Urea Nitrogen, decrease urine creatinine, decrease double kidney filtration rate etc. At the same time, the patient has other symptoms such as high blood pressure, high dropsy etc.
No matter the patient with low creatinine or high creatinine, they should pay serious attention to their health. Creatinine substances in the body are produced by muscle metabolism creatine, which are discharged outside the human body through kidney. Normally, because the muscle quantity is relatively stable, so the generated quantity is constant, the level of Serum Creatinine depends on how much creatinine which is discharged by the kidney. The compensation function of kidney is strong, if a pair of kidney both normal, as long as one kidney work well, the Serum Creatinine can maintain the normal level. That is to say, the damage level accounts for more than 50% of kidney, the serum creatinine begin to increase. Therefore, the early, low-grade renal function decline can’t reflected by Serum Creatinine.