Symptoms of Later Stages of Polycystic Kidney Disease

For most patients with Polycystic Kidney Disease, in the early stages, their kidneys are in normal size and shape, and there is no obvious discomfort. With the development of the disease, the cysts enlarge gradually. And then the size of the kidney enlarge with the cysts and the shape of the kidney will change abnormally， such as dysmorphism of pelvis and kidney calices, the damage to the normal structure of the renal papillae and pyramidal.

At the beginning, there may be just small number of cysts, but the whole kidney will be occupied gradually by the cysts, which may lead to that the kidney enlarges to the size of a football. According to the our small sample survey in kidney disease hospital, among the 1052 cases of polycystic kidney disease patients, the average length of their kidneys is 16cm. under the light microscope, we can still see the normal and unbroken renal structure among the space of the cysts. Then with the development of the disease, the following damage to kidney will successively appear, such as glomerulosclerosis, tubular atrophy, interstitial fibrosis and so on. All of these are caused by the compression of the cysts to the renal tissues which can lead to the ischemia and anemia. If the cysts ruptured, this may lead to the cysts infection, which may cause the purulence haemorrhage.

With the continuous enlargement of the cysts and the aggravation of this disease, more and more renal tissues and renal intrinsic cells will be damaged, and then the normal renal function can lose gradually. At last, the disease of polycystic kidney disease will aggravate to the end stage of renal failure.

If you have other doubts about the symptoms of Polycystic Kidney Disease, send an email to kidneyfailurecn@hotmail.com or consult online.