As one of the most common glomerulonephritis, IgA Nephropathy is considered to be an immune-complex mediated disorder. IgA Nephropathy refers to deposition of IgA Nephropathy (mainly) and other immune complex in mesangial area. IgA Nephropathy is not a simple disease for it has various manifestations and does not have fixed features in histology. According to Chinese medicine, if patients find the disease early, that is, they are clear about the symptoms of IgA Nephropathy, it is not difficult for them to treat the disease. So, what are the symptoms of IgA Nephropathy?
1. Macro-hematuria
30% to 50% of the IgA Nephropathy patients have macro-hematuria. Hematuria usually happens after pharyngitis and tonsillitis, which could happen within several to 24 hours after a cold, fatigue, vaccination, pneumonia and gastroenteritis. Macro-hematuria could remit spontaneously. The urine is brown without blood clot.
2. abnormal urinalysis
The clinical symptoms are micro-hematuria and proteinuria. Most of the patients are detected during physical examination or other check-up for other diseases. These type of patients have different clinical symptoms and pathological changes, whose prognosis is also different. Some patients can present hypertension and renal insufficiency.
3.Nephrotic Syndrome
Overall, Asians have a higher incidence than Westerners in terms of IgA Nephropathy patients getting NS, which is 10%∼17%. Nephrotic syndrome tends to happen to patients with serious pathological changes in glomeruli, in which many glomeruli are obsolescent with podocyte injured, mild interstium damaged or the crescent formed.
4. acute renal insufficiency
The incidence of acute renal insufficiency increases with age, which can be related to two types of pathological changes. One is that a lot of crescents are formed in glomeruli, and the other is a lot of red blood cell casts block the tubules during macro-hematuria. Some patients with acute renal insufficiency need hemodialysis.
5.chronic renal insufficiency
Renal insufficiency is, in most cases, the manifestation after a long-term course of IgA Nephropathy. Overt obsolescent glomeruli and the hardening of the kidney tubules are indicative of grim prognosis.
6.high blood pressure
A high percent of IgA Nephropathy patients start with hypertension as their initial symptom, which could also happen during the course. High blood pressure is factor leading to grim prognosis.
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