In the early stage Adult PKD, cysts are still small, so patients seldom have
obvious symptoms in this stage. With cysts growing and increasing, they can
compress surrounding renal tissue greatly. Then obvious symptoms appear. Pain on
waist usually happens firstly in early stage, but it is usually neglected by
most patients and no treatment can be taken to treat this symptom. Growing cysts
can replace more and more normal renal tissue, causing larger pressure on
surrounding renal tissue, and then End Stage Renal Failure appears.
Ⅰ. What is the hereditary regulation of Adult PKD?
Adult PKD follows the regulation of autosomal dominant inheritance, with
equal incidence to both male and female. Each of the parents suffers from this
disease, each of their children can get this disease at a risk of 50%, and this
number can increase to 75% if both parents have this disease. Children who do
not inherit PKD do not carry cystic gene, and their later generation won’t have
this disease if they marry with person who do not suffer from PKD. Besides
inherited from parents, patients who get this disease through gene mutation are
rarely seen.
Ⅱ. Does PKD have a serious illness condition when it happens?
Generally, there are no obvious symptoms in early stage PKD. For this reason,
most patients are not diagnosed as PKD in this stage. Common primary symptoms
that may appear in early stage of PKD are High Blood Pressure, Haematuria,
bellyache, and sometimes Urinary tract infection and Kidney Stone can be found
among primary symptoms.
Each disease develops from slowly and lightly to rapidly and seriously, and
PKD is no exception. Due to strong compensatory ability of kidney, there are
seldom obvious clinical symptoms when kidney is injured by cysts or other
external factors in the early stage. Patients can live, work and study
normally.
Ⅲ. How about the process of PKD developing into Uremia?
PKD is a kind of disease that so many cysts are growing in whole kidney.
These cysts are growing with age, causing pressure on kidneys, which can damage
renal structure and reduce nephron number. Finally, kidneys are so injured that
they can not maintain body’s normal life. At this moment, Uremia happens.
More exactly, the process of Renal Failure and Uremia is also the process of
Renal Fibrosis, and Renal Failure and Uremia is the result of more than 50%
kidney fibrosis.
Specialists on Kidney Disease point out that the earlier treatment is taken,
the better therapeutic effect can get. The best treating timing is before renal
function injury. Renal Failure and Uremia can be avoided completely if cysts of
PKD growth can be removed or controlled effectively in the early stage.
