If Polycystic Kidney Disease can not be controlled or treated effectively, it
may develop into Renal Insufficiency, or even Renal Failure and Uremia. Uremia
is not a independent disease name. Instead, it is a clinical syndrome of various
end stage Kidney Diseases. According to related tests and symptoms as well as
increasing physical indexes of serum creatinine and urea nitrogen, etc, disease
development can be divided into three stages—Renal Insufficiency compensatory
stage, azotemia stage and Uremia stage. Well, how to distinguish these three
stages?
In Renal Insufficiency compensatory stage, due to declined renal function,
glomerular filtrating rate decreases, but serum creatinine is not more than
178umoI/L and blood urea nitrogen is less than 9mmoI/L. Patients have no
symptoms in this stage. When serum creatinine is more than 178umoI/L and blood
urea nitrogen is more than 9mmoI/L, and patients still have no clinical symptoms
except tiredness, low appetite, and different degrees anemia, it means that this
disease has developed into azotemia stage. Uremia stage refers to that
glomerular filtrating rate decreases further, and serum creatinine is more than
445umoI/L as well as blood urea nitrogen is more than 20mmoI/L. In this stage,
patients have obvious symptoms.
It is terrible if PKD develops into Uremia which is a great threat to human
life. Therefore, PKD patients are suggested to receive effective treatment as
early as possible, especially in Renal Insufficiency compensatory stage when
cysts are still small.
