Nephritic Syndrome is not simply a disease. It is a group of syndromes in
Glomerular Disease. The main symptoms of Nephritic Syndrome mainly include mass
proteinuria, hypoproteinemia, serious edema and hyperlipidaemia.
1. Mass proteinuria
Mass proteinuria is a typical sigh of Nephritic Syndrome. As patient’s kidney
is aged, its structure changes a lot. As a result, the glomerular filtration
membrane can not play its role as before. The normal glomerular filtration
membrane can filtrate plasma protein selectively thus preventing much plasma
protein from filtrating from glomeruli. Therefore, only trace amounts of protein
appears in urine.
2. Hypoproteinemia
Serum albumin is below 30g/L. For patients with Nephrotic Syndrome, their
liver can produce more albumins. If they have enough protein and calorie intake,
their liver can produce about 22.6 grams albumin per day. However, as patients
lose much protein in their urine. When the liver’s compensation in producing
protein can not make up for the protein that loses in urine, the patients will
have hypoproteinemia.
3. Serious edema
In the early time, the patients have edema on their face, eyelid, and ankle
in the morning. However, as the disease develops, the edema will cover their
whole body. Some patients will have pleural effusion, ascitic fluid,
hydropericardium and so on. Some patients can not lie upward for serous edema.
There are two causes of edema. On one hand, the patients’ renal function
declines so it cause water and sodium retention in their body. It is an
important cause of edema. On the other hand, mass proteinuria causes the plasma
protein to decline. As a result, plasma colloid osmotic pressure decreases thus
the water in blood will infiltrate into tissues spaces and cause edema.
4. Hyperlipidaemia
It is caused by the lipid metabolism disturbance. For patients with Nephritic
Syndrome, various kinds of lipoprotein in blood will increase. Hyperlipidaemia
increase the risk of arteriosclerosis. Also, it is closely related to the
progressive glomerulosclerosis.
The above article has introduced the main symptoms of Nephritic Syndrome. If
you want to know more about the disease and it therapy, you can consult us on
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