For Adult Polycystic Kidney Disease,cysts’ growth features as below
aspects:
I. Different disease time
Different individuals of Polycystic Kidney Disease (PKD) get attacked at
different time, because of different environment, constitution and genes. Even
though patients from the same family in which family members usually have the
same assignment of genes, they are attacked at different time. It is also
reported that the attacking age of Polycystic Kidney Disease (PKD) tends to be
younger in each subsequent generation, that is, children get disease at earier
time than their parents.
II. The Number of cysts increases gradually
According to the evaluation, about 1%-5% of nephrons produce cysts under the
function of Polycystic Kidney Disease (PKD) genes. Each kidney has 100-200
million of nephrons, so we could calculate how many cysts will occur. But all
the potential cysts occur successively other than at the same time under various
conditions. The number of cysts grows rapidly once the appearance of cyst.
III. Grown cysts enlarge continuously
Hyperplasia occurs as cystic genes affect epithelial cell of kidney tubule,
and it can block the lumen of kidney tubule. Besides, cystic genes can change
the status of basement membrane of kidney tubule. There are two reasons which
arouse formed cyst to enlarge increasingly. On one hand, primary urine filtrated
by glomerulus can enter into cysts, on the other, epithelial cell of cysts
secrete liquid continuously.
IV. Cysts grow at an unbalanced speed
Due to infection, bad diet, sentimental disorder, toxic touchment, improper
activity, fatigue and other factors, two stages of cyst development, active
phase and stable phase, appears. This means that cyst can grow fast sometimes,
but stably and slowly in some other period.
