Polycystic Kidney Disease (PKD) is a type of genetic disease, so what is the
genetic media of PKD?
PKD abides by the law of autosomal dominant inheritance, so the morbidity of
male and female is equal; if one of the patients has PKD, 50 percent of their
children will carry this type of gene and have this disease, but if both of the
parents have PKD, the morbidity of their children will increase to 75 percent;
children without this type of gene won’t have this disease and their children or
children’s children won’t have this disease if they marry people without PKD.
Rarely there will be PKD caused by genic mutation instead of heredity.
What symptoms there will be at the early attacking of PKD? Will this disease
be very serious once it attacked?
Generally, PKD has no symptom at the early stage, many patients can’t be
diagnosed as PKD. The common first symptoms of PKD include hypertension,
hematuresis, abdominal pain, sometimes the first symptoms may be urinary tract
infection or Renal Stones.
The development of any disease is a process with order of priority, and PKD
is no exception. Because kidney has a strong ability of compensation, the
clinical symptoms of PKD are not very obvious at the beginning when kidney is
attacked by cysts and inflammation and other external factors, and patients’
daily life, work and study all go well.
How does PKD aggravate to uremia?
PKD means that there are various cysts, big or small, inside or outside the
kidney. These cysts will enlarge with the increase of ages, they will press
kidney, damage renal structures and reduce the amount of nephron which can
generate urine. Until kidney can’t maintain the normal life of human, then
uremia will occur at this time.
Accurately speaking, the developments of Renal Failure and Uremia actually
are the processes of renal fibrosis. And in fact, Renal Failure and Uremia are
the functional manifestations after the fibrosis of 50 percent of kidney.
What is the function of blocking renal fibrosis for patient’s condition in
treatment?
It is an important approach for controlling the aggravation of patient’s
condition to block renal fibrosis process effectively. Blocking renal fibrosis
means the reversion of damaged renal inherent cells, the recover of renal
function and the elimination of pathogenic factors.
The realization of blocking renal fibrosis is by the means of: first, reduce
cysts and reduce their pressure to surrounding tissue; second, recover the
function of damaged tissue in order to minimize the damage to kidney and
maximize the recover of function. Renal Insufficiency and Uremia can be
completely prevented if the cysts can be eliminated or controlled at early
stage.
Experts point out:
The earlier PKD is treated, the better effects will be. It is the best
treatment time that when renal function has not been damaged. So PKD patients
must remember this time. Patients can completely prevent Renal Insufficiency and
Uremia if they have eliminated or controlled cysts.
If cysts can’t be controlled well and Renal Insufficiency occurs, patients
must adopt treatment positively to block renal fibrosis. Control and reduce
cysts to decrease the pressure of cysts to surrounding tissue. Meanwhile
patients must block renal fibrosis and recover damaged tissue’s functions in
order to minimize the damage to kidney and maximize the recover of function.
