Presently, so many people are suffering from Polycystic Kidney Disease,
hereinafter referred to as PKD. What’s more, there usually are several person
may have this disease in the same family. Most patients may have the question
that why can I get this disease and How does it happen. Actually, besides
genetic factor, many other external factors are also importance inducements of
PKD occurrence. In a sense, PKD is the production of both internal factors and
external factors.
Generally, the internal factor is referred to congenital gene defect which is
the cystic gene on the 16th chromosome, and the 4th chromosome occasionally. As
for Adult Polycystic Kidney Disease, it belongs to autosomal dominant
inheritance with 100% penetrance, which means that each child may have 50%
possibility of getting this disease if one of their parents have cystic gene
problem. Besides, some patients may get this disease by gene mutation instead of
parents’ inheritance. For this reason, some PKD patients can have no family
history.
Many patients may ask that why this disease can have an unbalance developing
process though patients have the same gene problem. This can be explained by
different external factors. These acquired external inducements can be listed as
follows:
Firstly, various kinds of infections: infections can cause abnormal change to
organ internal environment, which is beneficial for cystic gene to be activated.
Then activity of cysts internal factors increases, promoting cysts formation.
Besides, infections on any part of body can get into kidney with blood,
affecting cysts growth.
Secondly, toxin: toxin accumulated in body can damage various cellular
organic tissue, resulting in disease happening or even threat to life. Besides,
toxin is also one of the main reasons of gene mutation and congenital
dysplasia.
From the above, it is obvious that PKD is the result of interaction of both
congenital internal factors and external inducements. Gene problem can not be
changed, but we can control the external factors through taking related
measures, which is significant to delay or prevent PKD occurrence. For this
reason, PKD patients should not lose confidence due to its genetic feature.
Instead, patients should learn more about this disease and have a correct
attitude to it. In this way, PKD patients will live a normal life as other
healthy patients. If you need other informations about this disease, you can
consult us online for free or you can send an email to kidney-treatment@hotmail.com.
