? What clinical expression of FSGS? Focal segmental glomerular sclerosis is morphology names pathology diagnosis, expression of FSGS is partial (focal) glomeruli and (or) some glomerular capillary loops (segments) lesions. The characteristic of focal lesions of FSGS, perform diagnostic heavily influenced by the organization derivative. First, the involvement of the deep medullary renal cortex along glomerular lesions, may appear obvious first tubular - interstitial injury. Proteinuria, nephrotic syndrome are the major clinical manifestations. The response to treatment of various diseases are poor, showed a chronic progressive disease process, eventually chronic renal failure occur. The disease is seen at any age, more common in children and adolescents. The average age of onset is 21 years. The male to female ratio was 2.2: 1. The disease incidence of several different reports, the incidence of children FSGS about 7% - 15% .Adults nephrotic syndrome patients, approximately 15% and 20% of FSGS. In recent years, tended to increase the incidence. Racial differences FSGS, multiple black.
The clinical expression
No single feature, idiopathic FSGS more with insidious onset of kidney disease as the first comprehensive, 10% to 30% of adult patients with mild proteinuria FSGS may manifest as asymptomatic proteinuria may be associated with common microscopic hematuria (2/3) with gross hematuria. Early in the disease appeared in blood pressure, renal dysfunction and acute renal tubular injury, but most patients during slowly. Upper respiratory tract infection, vaccination and other factors that may aggravate symptoms.
laboratory inspection
Over 80% of patients showed no selective proteinuria, molecular weight proteins in urine (such as IgG, C3, α2 macroglobulin) based. See pleomorphic red urine. Often, the performance of renal tubular dysfunction, such as renal tubular acidosis, low molecular weight proteinuria, glucosuria, urine dilution concentration function abnormalities. Common hypoalbuminemia and hypercholesterolemia, decreased serum IgG. Normal complement. 20% to 30% of patients positive for circulating immune complexes.
