In normal situation, the protein discharged every day is very little, about 150 mg. However, the patient nephrotic syndrome can download 2-20g every day, therefore. Proteinuria is the main clinical manifestation of nephrotic syndrome, is also the leading cause of affecting the outcome.
With the effects of various factors nephrotic syndrome, immune function abnormal patient changes, the most important thing is that the immunomodulatory cytokines and is not even cause kidney damage and disease of the glomerular basement membrane and its permeability increases. Therefore, produces many proteinuria.
Damage of proteinuria in patients with nephrotic syndrome
● For discharge of proteinuria and the change in protein synthesis, anti-freeze freezing actors in the body and factors to be uneven, and the freezing level of factor II, III, IV, V and X increased, which can trigger a messy environment in which the normal freezing mechanism, platelet activity, thrombolysis body are greatly affected. Therefore, the blood of patients with nephrotic syndrome is in a state of high freezing, which is quite dangerous to the formation of thrombus.
● Proteinuria can make all kinds are lost proteins in blood plasma, and then wakes dysbolism or dysfunction of some systems, and even some complications. As hypoalbuminemia itself or low tire pressure attached which can cause the lipid metabolism alters its function, downloading and lecithin cholesterol acyl invertase urine, HTC cholesterol is carried out, which may change further the proportion and activity of various lipoproteins and damages blood vessels and endothelial function lomerulus, burying the hidden danger for cardiovascular disease.
● Other types of proteins can get high after the proteinuria, and the corresponding result can arouse such as the loss of binding globulin vitamin D, which can result in abnormalities in vitamin D and calcium metabolic disorders . For children, the adequacy of vitamin D can affect bone growth, loss of thyroid binding globulin can trigger thyroid dysfunction, affecting the growth of children.
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