Lupus nephritis (LN) is systemic lupus erythematosus (SLE) involving the kidneys caused by an immune complex glomerulonephritis, is SLE major cause of death and major complications. Lupus Erythematosus (systemic lupus erythematosus, SLE) is a clinical manifestation of multiple system damage symptoms of chronic systemic autoimmune disease, having anti-nuclear antibody-based serum from a number of different autoantibodies. This disease in remission and acute episodes are characterized by alternating, no offal (kidneys, central nervous system) bad prognosis damage. The prevalence of this disease in our country 1/1000, higher than in Western countries report 1/2000, is more common in women, especially women of childbearing age 20-40 years old.
Pathogenesis
This disease is endogenous body (in person) antigens produce immune complex disease. B cells of SLE patients, the proliferation of highly active, producing a variety of autoantibodies, such as anti-nuclear antibody, anti -single- stranded, double-stranded DNA antibodies, the anti - histones, the anti - RNP antibody -SM anti ect. All of the above substance are anti - nuclear (antigen) antibody. Other anti - cytoplasmic antigen-antibody, for example anti - anti -plaquetas ect erythrocyte antibodies - ribosomal against blood cell surface antigens, anti drug - lymphocytes, antibodies. These antigens and antibodies to form immune complexes disease, deposited in various body tissues, eliciting an immune response, various tissue and organ damage. The SLE is a heterogeneous disease, different patients may variar.Calma immune abnormalities in glomerular immune complexes via the classical pathway of complement activation, the patients serum complement Clq, C3, C4 ingredients are significantly reduced, the strings solution prepared and levels of factor B in normal or slightly decreased. In addition, infiltration of white blood cells, platelets, and intrinsic renal cells in the inflammatory state, is capable of producing a variety of cytokine-mediated inflammatory more injuries.
