No heat of diabetic nephropathy cause of disease and the mechanism of pathogenesis. At present there are many causes pensa. Bajarfondo hereditary and some common risk factors pathogen.
1. Genetic factors
The man taller than women diabetic nephropathy occurs. Research Comes Together in the same environment, Africa and Mexico easier happens that white diabetic nephropathy, in the same family, some families suffer FACL diabetic nephropathy, therefore, be the genéticos.La factors in type 1 diabetes 40% -50% microalbuminuria, type 2 diabetes during the observation period of only 20% -30% diabetic nephropathy occurred, toados soon as possible genetic factors play an important role.
2. The mechanical kidney blood flow abnormal
Early stage diabetic nephropathy can observe the mechanical kidney blood flow abnormal. He showed great perfusion and glomerular hyperfiltration, renal flow and glomerular filtration rate of blood (GFR) increased, and then increase the level of protein intake increased more significantly.
3. Blood sugar creates metabolic disorders
Higher glucose mainly through the kidney blood flow changes mechanical and metabolic abnormalities cause kidney damage, kidney damage cause metabolic disturbances include; ① partial disorder of glucose metabolism in renal tissue, can pass the formation of non-enzymatic glycosylation of advanced glycation end metabolites (AGES); ② Atrava multiple Alcohol way; ③ Diacylglycerol - activated protein kinase pathway c; ④ have glycosaminoglycans road metabolic disorders. Referred addition to participating in the hyperfiltration early metabolic disturbances, it is more important to promote thickening of the basement membrane and accumulation of glomerular extracellular matrix (GBM), increases glomerular hair.
4. Hypertension
Almost any diabetic nephropathy toados no hypertension in type 1 diabetes, hypertension and microalbuminuria nephropathy occurred in parallel, but in type 2 diabetic nephropathy in frequency appear, controlling blood pressure is closely related to the development of diabetic nephropathy.
5. Vasoactive substances metabolic alterations
During the development of diabetic nephropathy are possible variety of vasoactive substances metabolic disorders. Sparse including endothelin, prostaglandin family and other growth factors and metabolic disturbances.
Above mentioned are all introductions to the causes of diabetic nephropathy, if you still have more questions than other aspects of diabetes, can send a letter about your situation kidney-support@hotmail.com, we can give you an answer within 12 hours specialty.
