Laboratory tests
① General inspection: The majority of patients (80%) had a moderate anemia (anemia pigmented cells are positive) rarely showed hemolytic anemia, thrombocytopenia, 1/4 patients with pancytopenia, 90% accelerate ESR. Globulin patients was significantly higher.
② Immunological tests:
(1) Antinuclear Antibody: Sensitivity of antinuclear antibodies in 90%, but lower specificity in mixed connective tissue disease, rheumatoid arthritis, Sjogren's syndrome etc can be positive. Therefore, this test is not the only indicator for diagnosis, can be used as indicators of disease activity reference, however, its titer and severity of renal disease or not has nothing to do.
(2) anti-dsDNA antibodies: an antibody that is diagnostic marker of SLE, the sensitivity of 72%, the change in titer and is closely related to the activity occasionally lupus.Sólo syndrome in sjogren, active rheumatoid arthritis and hepatitis are positive.
(3) antibodies and anti-anti-RNP Sm: Sm antibodies common in 25% -40% of patients illness, common anti-RNP antibodies in 26% -45% of patients. Anti-Sm antibody specificity in the diagnosis of systemic lupus erythematosus high.
(4) anti - histones: Common in 25% -60% of patients. Specificity are better, although common in rheumatoid arthritis and Sjogren's syndrome etc.
(5) antibodies and anti-anti -SSB SSA: The first is common in 30% -40% of patients, the latter is only 0-15% .Both antibodies were mainly observed in Sjogren's syndrome.
(6) Other antibodies: SLE and a variety of other autoantibodies, such as hemolytic anemia, anti-erythrocyte antibodies, necrotizing vasculitis and neutrophil cytoplasmic antibodies (ANCA) etc. in recent years special attention antiphospholipid antibodies, common in 34% of patients .
(7) Complement: C3, C4, CH50 can reduce, in particular, C3 decreased activity of lupus is a sensitive and reliable determine indicators.
(8) Band lupus Skin: Epidermis of non-lesional skin and dermis town link, using direct immunofluorescence, may have IgG and (o) C3 granulated calm band yellow-green fluorescence. The disease is common in patients with more than 70%.
(9) Other: Rheumatoid factor (RF) and cold globulin test can be positive activists pathological changes.
Above is the differential diagnosis of lupus nephritis? If you are interested in our items, still pay attention to us please! We articles on various diseases of kidneys, include rudimetos, symptoms, treatment, diet and Fitness has all the information? If you have any problem, you can consult our experts online or leave a message below!
