1. What disease is ill?
Diabetic nephropathy is a type of traditional diagnosis (this is a type of secondary nephropathy) as traditional explanation is correct, is the complication of diabetic microvascular mainly is diabetic glomerulosclerosis, is a type of pathological changes of glomerular dominated by vascular damage .According to the current most advanced and cutting-edge cytology is the disease of diabetic glomerular basement membrane.
2. How sick Diabetic nephropathy?
Because insufficient insulin or insulin opposes resistant, lead blood sugar up, blood sugar rises, it can lead to renal hemodynamic changes in kidney, high cholesterol, hypertension, and hyperglycemia appears, while producing large amounts of lipid peroxidation free radicals, and increased glycosylated hemoglobin glycation end products generated, these causes can injure mesothelial cells in glomerular endothelial cells are injured, may attract inflammatory cells infiltrate the blood while pound inflammatory mediators. These inflammatory mediators can infiltrate between mesangial area, leading to extend mesangial cells, epithelial cell fusion process produces dense foot drops, epithelial cells detached from the basement membrane thickening, stenosis cavities tube basement membrane, cease blood kidney failure and lack of oxygen causes the barrier function is impaired glomerular nuclear electronegative then can not prevent dripping blood protein, the protein appears +; patient's condition progressed, glomerular basement membrane collagen type 4 nucleic acids messenger increased sugar ago that thickening base film. by last article, the formation of diffuse lesions, mesangial nodular glomerulosclerosis occurs at this time may appear urea nitrogen and creatinine rise in clinician, the theory of this disease, we easily know that a Kurdish incompletely disease is that "damage glomerular basement membrane ".The symptoms are proteinuria and pathological symptoms of this series.
3. Why you sick this disease?
The cause of diabetic nephropathy especially are primary or secondary (eg genetic factors and environmental factors, lack of absolute and relative insulin, insulin resistance, hyperglycemia, metabolic syndrome) while in the pathogenesis of immune regulation associated with dysfunction, causes blood sugar rises in body intrinsic glomerular cells a number of pathological changes, it leads thickening of the glomerular basement membrane, tube cavities stenosis, vasoconstriction, microcirculation failure leave the blood and oxygen kidney failure, the capillaries laglomerular around wounded and tubular are also inflammatory infiltration, starts renal fibrosis, the onset of intrinsic renal cell phenotype, extracellular matrizes integrates many, supplanting healthy intrinsic renal cells, development of glomerular sclerosis, necrosis. We therefore call diabetic glomerular basement membrane disease.
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