IgA nephropathy is an autoimmune disease with deposits of immunoglobulin A (IgA) in the mesangial area. It is a progressive disease and a number of symptoms appear as reduced renal function. The swollen ankles and protein in the urine are two main symptoms of IgA nephropathy.
The protein in the urine of IgA nephropathy
Protein is an important substance in the human body. She is a major source of energy and also involves the creation of some hormones. It also forms antibodies that help prevent infection, illness and disease, etc.
In normal condition, the kidneys filter out excess fluids and wastes from the body and preserve useful substances in the body. However, IgA nephropathy, the kidneys do not work normally, many proteins leaking into the urine by the kidneys, this is the reason of proteinuria.
The swollen ankle IgA nephropathy
Protein in the urine may be a factor attributable to swollen ankles in IgA nephropathy. Protein is like a sponge and can hold fluid in the blood vessels. Lower levels of protein in the blood vessels do not maintain fluid in blood vessels as before. The result is that a large amount of liquid is a filter in the subcutaneous tissue, resulting in swelling.
In addition, fluid retention in the body can also contribute to the swelling of the ankles in IgA nephropathy. An important function of the kidney is removed the excess fluids from the body to keep the content of the liquid level in the body. However, when the kidney stops functioning properly, excess liquid can not salt the body, therefore, excess liquid remaining in the body. Because gravity, swelling appears on the lower body parts for example the feet. This is the reason for swollen ankle IgA nephropathy.
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