(1) Proteinuria mesangial toxicity:
In the model of renal failure, can be observed in the whey proteins in glomerular mesangial accumulation in mesangial macromolecules that can cause buildup cell injury, matrix synthesis powers hyperplasia membrane, resulting in glomerulosclerosis. Proteinuria, glomerular nephropathy model density lipoprotein low density lipoprotein (LDL) and very low (VLDL), apolipoprotein B and apolipoprotein A deposition of these aggregates over time can lead to glomerulosclerosis.
(2) The cell toxicity action of proximal tubular proteinuria:
When proteinuria, renal tubular epithelial cells in the amount of protein increased, increased lysosomal activity, suggesting that the protein causes lysosomal overflow tubular cell suspension, cell injury can stimulate further inflammation and the formation of scars.
(3) Changes induced tubular proteinuria in cell biology:
Many kidney disease with excessive cell proliferation are proteinuria represents a non-adaptive response, leading to kidney failure. More and more evidence that the protein can be directly conditioned tubule cell function, changing the growth characteristics of cytokines and matrix proteins and their phenotypic expression can lead to a small tube basolateral PDGF release, FN, and MCP-1 induced fibrosis.
(4) The tubulointerstitial hypoxia-induced proteinuria emphasis:
Resorption proteinuria extra energy to digest large quantities of protein, which can cause hypoxia tubule cells, resulting in cellular damage caused by a small tube.
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