The cause of high serum creatinine
Changes in serum creatinine concentration, primarily by the ability of glomerular filtration rate (GFR) to decide. Filtration capacity decreases, the concentration of creatinine. Most average serum creatinine greater than normal renal damage values, serum creatinine may more accurately reflect the status of renal injury, not sensitive indicators. Because the normal glomerular filtration rate is reduced to 1/3, serum creatinine were significantly increased. Which means that, due to the metabolic capacity of the human kidney, when kidney damage is usually less obvious discomfort, so a lot of people when the real nausea, vomiting, dizziness, indeed, a serious kidney damage and then began to rise significantly in serum creatinine.
The cause of low serum creatinine
Description of renal function in patients with serum creatinine when a problem is high, the ability of the kidneys decreases metabolic wastes, toxins in the body can not be eliminated normally, then what is opposed to the reason for the low serum creatinine? the reason is due to the low serum creatinine in the kidney by a variety of causes of violations, damaging the first inherent kidney cell phenotype transformation takes place, the formation of pathological changes in the kidneys to stimulate fibroblasts into myofibroblasts in, and at the same time, and stimulate the inherent violation of normal renal tissue, the appearance of the same disease, thus forming a kidney from one point to plane, from the local to the general, expanding the spread of process kind of excitement to enter the trauma unit mass (renal function ie period of injury), this time due to kidney continuous damage, excreting waste function decreases, causing the accumulation of toxins in the body, such as creatinine, and therefore appears in the blood creatinine, blood urea nitrogen, creatinine in urine decreased renal filtration rate and so on. At the same time, the patient will have high blood pressure, high degree of inflammation and other symptoms elsewhere in the body.
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